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This study is now complete and registered with ClinicalTrials.gov, NCT03600480

In the SURMOUNT-2 study, which involved 938 adults with obesity or overweight and T2D, tirzepatide showed significant weight loss effects of 13.4% and 15.7% for the 10 and 15 mg doses, respectively, with over 80% of participants experiencing at least a 5% weight loss [92]

The effect of TG is mediated by various factors, including nuclear factor-kappa B (NF-B), protein kinase C and -adrenergic receptor signaling pathways (35)

Eye Problems: Acute myopia and secondary angle-closure glaucoma have been reported, necessitating immediate medical attention if blurred vision or eye pain occurs